Pamela Silver

Pamela Silver

Principal Investigator

Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.

Read more here.


Jeffrey Way

Jeffrey Way

Senior Staff Scientist

Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.


Elizabeth Libby

Elizabeth Libby

Departmental Fellow, Systems Biology

PhD Physics, University of Pennsylvania
BS Physics, Stanford University

Elizabeth is interested in how bacterial populations regulate antibiotic tolerance and the appearance of rare cells with extreme phenotypes. She is currently designing new ways to measure bacterial signaling system activity.


Postdoctoral Fellows

bryan

Bryan Hsu

Ph.D. and M.S. Chemistry, MIT

B.S. Chemical Engineering, UC Berkeley

B.S. Materials Science and Engineering, UC Berkeley

Has worked in the fields of surface science, antimicrobial coatings, biomaterials, and controlled drug delivery. Now studying bacteriophages of the human gut and engineering formulations for their oral delivery.

david

David Riglar

Human Frontier Science Program Postdoctoral Fellow 2015

NHMRC – RG Menzies Postdoctoral Fellow 2014

PhD Malaria Cell Biology, University of Melbourne

BSc (Hons) Biochemistry and Molecular Biology, University of Melbourne

David is a postdoc interested in the potential for synthetic biology to help us to better understand human disease. He is currently working to design diagnostics of gut disease.  Profile here.

jess

James Kuo

PhD Chemical Engineering, Stanford

BS Chemical Engineering, University of Illinois at Urbana-Champaign

Amateur still trying to turn pro. Looking at controlling and recoding cells, after previously playing with natural product biosynthesis. Hoping to imagine again.

 

kelsey

Kelsey Sakimoto

Harvard University Center for the Environment Fellow 2016

PhD Chemistry, UC Berkeley

BS Chemical Engineering, Yale University

Kelsey is a reformed materials chemist that has embraced the wet and squishy world of biology. He’s very much against the idea of starving and is currently devoting his time to finding nifty science-y ways around that.

Michael Melfi

Ph.D. Chemistry, Stanford University

B.S. Biological Sciences, Cornell University

Interested in the connections between energy dissipation and accuracy of biochemical networks and oscillators, as well as in engineering low-cost networks in cells.

 

roger

Roger Larken Chang

Life Sciences Research Foundation Fellow 2014

PhD Bioinformatics and Systems Biology, UC San Diego

BA Molecular and Cell Biology, UC Berkeley

Engineering synthetic RNA nanostructures that self-assemble in bacterial cells. Developed landmark model for structural systems biology of metabolism and applying towards study of radioresistance in D. radiodurans. Profile here.

tobias

Shannon Nangle

2017 NIH F32 NRSA Postdoctoral Fellow

Ph.D. Pharmacology, University of Washington

Shannon is a postdoc interested in creating human-plant hybrids to live on Mars (but is totally not working on that).

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Tobias Giessen

Leopoldina Postdoctoral Fellow 2014

PhD Biochemistry, Philipps-University Marburg

M.S. Chemistry, Philipps-University Marburg

Enzymology, Combinatorial Biosynthesis, Compartmetalization in Bacteria, Synthetic Metabolons and Bio-Inorganic Hybrid Materials

tobias

Yu Heng Lau

Sir Henry Wellcome Postdoctoral Fellow 2015

PhD Chemistry, University of Cambridge

Yu Heng is a new postdoc and lapsed organic chemist with an interest in metabolic engineering and genome recoding.

Erika Olson 

Ph.D. Chemical Biology, The Scripps Research Institute

A.B. Chemistry, Cornell University

Erika is a former peptide chemist interested in improving human-environmental relations. She is currently investigating how viruses play Jedi mind tricks on their host. 


Graduate Students

isaac

Isaac Plant

 Ph.D. Candidate in Bioengineering

M.Sc. in Philosophy and Public Policy, London School of Economics and Political Science

Isaac’s work focuses on harnessing the unique biology of cyanobacteria to construct new microbial engineering paradigms. He is also interested in the policy and ethics of biological research, and has far more opinions than is generally considered healthy.

andy

Andy Shumaker

 Andy studies the gut microbiota and probiotic bacteria. He enjoys exploring the outdoors, playing sports, making beer and eating croissants.

emma

Emma Spady

PhD Candidate in Chemical Biology

B.A. Biochemistry, Swarthmore College

Emma is currently synthesizing novel steroids in mammalian cells by combining enzymes from different animals, bacteria, and fungi. In her spare time, she sings in the Dudley House choir and hangs around art museums.

finn

Finn Stirling

Finn is a student from the UK, and is interested in making sure the stuff that comes out of you is dead and has no friends. I am looking to recruit undergrads or anyone else to help me in this endeavor.

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Jernej Turnšek

PhD Candidate in Biological and Biomedical Sciences

Diploma in Biotechnology, University of Ljubljana, Slovenia

Jernej is interested in understanding the molecular mechanisms behind intricate nanoscale patterning of naturally occurring biomaterials. He can dunk, collects vinyl records and trains to become an Ironman. More about Jernej.

cam

Jungmin Lee

B.S. Chemistry, Duke University

Jungmin is a graduate student in the Chemistry and Chemical Biology Program. She is interested in protein therapeutics and mammalian synthetic biology.

katherine

Katherine Redfield

M.D. Candidate, Harvard Medical School

Harvard-MIT Health Sciences and Technology (HST)

BS Mathematics, MIT

Katie may be no Doogie Howser, but she’s still full of pep about her second career as a budding physician-scientist. She would love to talk your ear off about fusion proteins, dancing and the best coffee shops to camp out in. Her enthusiasm is fueled by a diet of red bull and leftover conference room pizza.

marika

Marika Ziesack

Marika is a Graduate Student in the Biological and Biomedical Science Program. She works on engineering microbes for renewable production of chemicals.

marika

Nathan Rollins

Nathan is investigating the molecular events that enable conditional behavior in biological systems. He is adding layers of requirement to proteins that function in these systems so they may only act when specific circumstances are met. Particularly, he is teaching cytokines when to pull the trigger on cell death.

sasha

Sarabeth Buckley

NSF Fellow

B.S. in Biology and Environmental Science, Tufts University

A plant chemist escaping geology to synthetic biology, Sarabeth is fascinated by plant microbial interactions and driven to address climate change. She wants to enhance plant growth and sequester CO2 with the bionic leaf and protein microcompartments. When not biking between campuses, she can be found running, dancing, or baking crazy cakes.

sasha

Sasha Naydich

Ph.D. Student in Bioengineering

B.S. Chemical & Biomolecular Engineering, Cornell University

 Sasha is interested in engineering gut microorganisms to diagnose and treat infection and disease, as well as the translation of discoveries from the lab to real-world application. Outside the lab, Sasha enjoys hiking, skiing, and mountain biking. Profile here.

suhyun

Suhyun Kim

Suhyun is engineering gut bacteria to perform useful functions in humans. She enjoys dancing Rock’n’Roll and Zumba.

Yukiye Koide 

Yukiye is a recent Harvard graduate with a degree in Biomedical Engineering. She is currently working on ~virus stuff~ and hopes to eventually get a graduate degree in bioengineering. In her spare time, she relives her college days and joins the Harvard Band in cheering various sports teams to victory.

Florian Bieberich

Florian is investigating how viral proteins interact with the innate immune response. Further, he is interested in the field of protein fusion and synthesis. In his free time Florian plays squash, trains for a triathlon and enjoys good old vinyl records.

 

 Kira Sarup-Lytzen

Kira is a visiting Ph.D. student from Denmark working with Finn to expand the catalogue of conditional kill switches in E. coli. Outside the lab, Kira enjoys hanging out at breakfast & coffee places with good people, and being outside with sunglasses on as soon as the sun appears.

Daniel Loh 

PhD Candidate in Chemistry and Chemical Biology

BS Chemistry, Yale University

Dan (not to be confused with Dan) is interested in renewable chemistry and is even more interested in getting microbes to do it for him. He also thinks self-replicating cyborg bacteria would be cool.

Nathalie Gruber

Nathalie is working with Elizabeth and Isaac on building living sequence sensors. She wants to artificially increase the natural competence of bacterial cells to efficiently uptake DNA samples. Her interests are various like dancing, painting and e-guitar but she is mostly seeking for new adventures and challenges.

 


 

Research Staff

alan

Andrew Verdegaal

BS and MA Molecular, Cellular, Developmental Biology at UC Santa Barbara

Andy is working on engineering and utilizing bacteria as diagnostic and therapeutic tools in order to combat disease. He enjoys rowing, hiking, and even the exposure to true winter weather.

Kathy

Kathleen Buhl

Lab Manager

Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.


Undergrads

Jason Lee

Jason is a Harvard undergraduate who is currently studying “science,” whatever that means, and is considering dabbling in the practical world of business. He is currently mentored by the space-visionary Shannon Nangle. In his free time, he likes to read the Wall Street Journal and peruse the delicious fruits in Haymarket.

Maya Ordenez

Rachel Barocio


Recent Alumni

Alina Chan

Jessica Polka

Connor Horton

John Oliver

Alan Pacheco

Leon Liu

Ryan Richardson

Stephanie Hays

Brendan Colón

Kriti Lall

Michael Baymv

Joshua Grossman

Marta Tomaselli

Una Choi

Avi Robinson-Mosher

Devin Burrill

Matthew Robinson

Matthew Niederhuber

Cameron Myhrvold

Clovis Basier

Kevin Hof

Michiel Karrenbelt

David Lips

Gladys Kibunyi

Johannes Bues

Joost Verduijn

Drew MacKellar

Audam Chhun

Thomas Perli

Tyler J Ford

Lauren Kennedy

Matthew Mattozzi

Wade Hicks

Anna Chen

Buz Barstow

Wiggert Altenburg

Pia Mach

Takashi Imada 

Elena Schafer

Max Van der Ploeg 

Michael Tscherner

Nabeel Nissar

Sherry Gao

Samuel O’Keefe

Nicholas Wong

Aashna Shah

Ashton Omdahl

Disha Trivedi

Elizabeth Redfield

Lorena Lyon