Pamela Silver

Pamela Silver

Principal Investigator

Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.

Read more here.


Jeffrey Way

Jeffrey Way

Senior Staff Scientist

Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.


Roger Larken Chang

Roger Larken Chang

Associate Lab Director

Life Sciences Research Foundation Fellow 2014
Ph.D. Bioinformatics and Systems Biology, UC San Diego
B.A. Molecular and Cell Biology, UC Berkeley

Roger’s current research interests are in the study of proteome-wide oxidative stress resistance, as in the radioresistance of the polyextremophile Deinococcus radiodurans, and in engineering protein therapeutics to induce suspended animation in mammalian cells for preservation and to confer environmental stress resistance. Roger previously developed landmark models for structural systems biology of E. coli metabolism to identify growth-limiting enzymes for thermotolerance, antibiotic mechanisms, and human renal metabolism to characterize drug off-target effects in silico.


CV


Elizabeth Libby

Elizabeth Libby

Departmental Fellow, Systems Biology

Ph.D. Physics, University of Pennsylvania
B.S. Physics, Stanford University

Elizabeth is interested in how bacterial populations regulate antibiotic tolerance and the appearance of rare cells with extreme phenotypes. She is currently designing new ways to measure bacterial signaling system activity.


Research Scientists

Shannon Nangle

2017 NIH F32 NRSA Postdoctoral Fellow

Ph.D. Pharmacology, University of Washington

Shannon is a a technical lead on a Wyss Institute Project focused on commercializing a CO2-based fermentation system for the production of tailored polymers. She is committed to developing synthetic biology and fermentation approaches to promote a more sustainable relationship with the planet.

Marika Ziesack

Ph.D. Biological and Biomedical Science, Harvard University

Marika Ziesack is a Research Scientist working on the Wyss Institute Project “Circe” which aims to convert carbon dioxide waste streams into biodegradable polymers. Her research interests include metabolic engineering of non-standard bacteria, fermentation of sugar and gas feedstocks and bio-process design and analysis. She received her B.Sc. and M.Sc. from Heidelberg University and Ph.D. from Harvard University.

Dominik Niopek

Ph.D. Biology, Heidelberg University
B.Sc. & M.Sc. Molecular Biotechnology

Dominik is a group leader for synthetic biology with focus on optogenetics and CRISPR-based tool development in the Health Data Science Unit at Heidelberg University Hospital and BioQuant, Germany. He is excited to visit the Silver lab to work on novel protein therapeutics for pancreatitis treatment.


Postdoctoral Fellows

James Kuo

2017 NIH F32 NRSA Postdoctoral Fellow

Ph.D. Chemical Engineering, Stanford

B.S. Chemical Engineering, University of Illinois at Urbana-Champaign

Amateur still trying to turn pro. Looking at controlling and recoding cells, after previously playing with natural product biosynthesis. Hoping to imagine again.

 

Erika Olson 

Ph.D. Chemical Biology, The Scripps Research Institute

A.B. Chemistry, Cornell University

Erika is a former peptide chemist interested in improving human-environmental relations. She is currently investigating how viruses play Jedi mind tricks on their host.

Timothy Chang

Ph.D. Bioengineering, Georgia Institute of Technology

S.B. Chemical Engineering, Massachusetts Institute of Technology

Tim is currently developing high throughput analyses of viral genes and their effects on intracellular signaling. In short, studying the viruses of today to better defend against the diseases of tomorrow.

Dan Nguyen

Ph.D. Biophysics and Bioengineering, UC Santa Barbara
M.S. Nanoscience, Arizona State University
B.S. Biochemical Sciences, Harvard University

Dan has worked in a variety of scientific fields, including tumor angiogenesis, non-canonical amino acids, single-molecule force spectroscopy, self-assembled DNA nanostructures, and phase separation in biology. In the Silver lab, he is adding “little water bears” to this eclectic list.

Michael Veling

Ph.D. Biochemistry, University of Wisconsin, Madison
B.S. Chemistry and Biochemistry, UMass Amherst

Mike wants to use biology to solve problems big and small. He is hoping his current project will allow him to travel across the galaxy in a biostatic sleep someday.

Suhyun Kim

Ph.D., Harvard University

Suhyun is engineering gut bacteria to perform useful functions in humans. She enjoys dancing Rock’n’Roll and Zumba.

Rebecca Sherbo

2019 Schmidt Science Fellow

Ph.D. Chemistry, University of British Columbia

Rebecca is a chemist trying her hand at some biology for her postdoc. She wants to use microbes to convert CO2 to chemicals and fuels.

Monica McNerney

Ph.D. Bioengineering, Georgia Institute of Technology

B.S. Chemical Engineering, University of Notre Dame

Monica is interested in using synthetic biology to design smarter diagnostics and therapeutics.

Tai Ng

Ph.D. Chemistry, Harvard University

Tai is a postdoctoral fellow in Pam Silver’s lab who is interested in synthetic biology.


Graduate Students

Nathan Rollins

Nathan is investigating the molecular events that enable conditional behavior in biological systems. He is adding layers of requirement to proteins that function in these systems so they may only act when specific circumstances are met. Particularly, he is teaching cytokines when to pull the trigger on cell death.

Jungmin Lee

B.S. Chemistry, Duke University

Jungmin is a graduate student in the Chemistry and Chemical Biology Program. She is interested in protein therapeutics and mammalian synthetic biology.

Katherine Redfield

M.D. Candidate, Harvard Medical School

Harvard-MIT Health Sciences and Technology (HST)

BS Mathematics, MIT

Katie may be no Doogie Howser, but she’s still full of pep about her second career as a budding physician-scientist. She would love to talk your ear off about fusion proteins, dancing and the best coffee shops to camp out in. Her enthusiasm is fueled by a diet of red bull and leftover conference room pizza.

Daniel Loh 

PhD Candidate in Chemistry and Chemical Biology

BS Chemistry, Yale University

Dan (not to be confused with Dan) is interested in renewable chemistry and is even more interested in getting microbes to do it for him. He also thinks self-replicating cyborg bacteria would be cool.


Daniel Heid

M.Sc. candidate Molecular Biotechnology, Heidelberg University (Germany)
B.Sc. Molecular Biotechnology, Heidelberg University (Germany
)

Daniel is a visiting student interested in protein therapeutics and synthetic biology. He is working on novel fusion proteins for the treatment of pancreatitis.


Kasia Kready

B.Sc. Biomedical/Medical Engineering, Dartmouth College

Kasia is a grad student in the Silver lab.


Kailyn Doiron

Ph.D. student in Systems, Synthetic, and Quantitative Biology
M.A. Biotechnology, Boston University
B.A. Biochemistry and Molecular Biology, Boston University

Kailyn is a graduate student in SSQBio and is a molecular and cell biologist at heart. She is very interested in making your cells do things they don’t normally do in order to create novel therapeutics. She was a competitive dancer in a past life and can be seen busting a move in studios or her kitchen in her free time. She loves binge-watching TV and tending to or talking about her five cats and seven orchids.


 

Research Staff

Kathleen Buhl

Lab Manager

Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.

Christine Zheng

Christine recently graduated from Harvard with a degree in Chemistry, although she never was and never intends to be a “real chemist.” She likes to put DNA places it doesn’t normally go and seeing what happens. In her free time, she enjoys painting, reality TV, and explaining jokes to people.

Priya Jani

Priya joined the lab in December 2018 and is studying disordered proteins to inform the design and delivery of novel therapeutics. Outside of lab, Priya enjoys gardening, Flamenco, and Billie Holiday.


Lauren Jiang

Lauren is a research assistant in the Silver lab.


Hadley Weiss

Hadley recently graduated from Harvard, where they studied bioengineering, although they are still a little unclear on what bioengineering actually means. Outside of lab, they can often be found whipping up much tastier experiments in the kitchen, laughing at jokes on the Internet, and occasionally reading an actual book.


Undergrads


Recent Alumni

Julian Stanley – grad student, MIT

Tobias Meisinger – grad student, Eberhard Karls University Tübingen

Davide De Marchi – grad student, University of Pavia

Louis Bricout – grad student, ENS Lyon

Aaron Rosenstein – grad student, Queen’s University

Fabian Springer – grad student, Heidelberg University

Toluwalese Oladitan – undergrad, Harvard University

Nélida Leiva Eriksson – postdoc, Lund University, Sweden

Fernando Barbosa – Ph.D. candidate, University of Campinas, Brazil

Bryan Hsu – Assistant Professor, Dept of Biological Sciences, Virginia Tech

Finn Stirling – University of Cambridge

Sarabeth Buckley – University of Cambridge

Michael Melfi – VL50

Yukiye Koide

Juline Savigny – masters student, Ecole Normale Superieure

Jonathan Naccache – masters student, Sup’Biotech Paris

Jérôme Zürcher – undergrad, ETH Zürich

Colin Molloy – undergrad

Maya Ordonez – undergrad, University of Chicago

Julia Rogers – undergrad, Emory University

Teagan Stedman – undergrad, Harvard University

David Riglar – Assistant Professor, Imperial College London

Sasha Naydich – Consultant

Emma Spady – Postdoc

Lorena Lyon – NOVA | PBS

Disha Trivedi – Harvard University

Jernej Turnšek – Research Fellow at J. Craig Venter Institute

Isaac Plant – Engineering and Product Development at Elm Innovations

Nathalie Gruber – Graduate student, University of Applied Life Sciences Vienna

Tobias Giessen – Assistant Professor, Dept of Bioengineering, University of Michigan

Jason Lee – Harvard University

Rachel Barocio – University of California Santa Cruz

Kassandra Boada – University of Massachusetts Amherst

Andrew Verdegaal- Graduate student, Yale University 

Andy Shumaker- Indigo

Florian Bieberich- Graduate student, Ruprecht Karls University Heidelberg

Yu Heng Lau- Assistant Professor, University of Sydney 

Kelsey Sakimoto- KulaBio

Kira Sarup-Lytzen- Graduate Student, Novo Nordisk Foundation Center for Biosustainability in Copenhagen

Jessica Polka- Director, ASAP Bio

Connor Horton- Undergraduate, Harvard University

John Oliver- ZBiotics

Alan Pacheco- Graduate Student, Boston University

Leon Liu- Senior Data Engineer, Athenahealth

Ryan Richardson- Postdoctoral Fellow, University of Maryland

Stephanie Hays- Postdoctoral Researcher, UC Berkeley

Brendan Colón-Data Scientist, Amazon

Kriti Lall- Investment Banking

Michael Baymv- Assistant Professor, Harvard Medical School

Joshua Grossman

Marta Tomaselli- Graduate Student, University of Cambridge

Una Choi- Undergraduate, Harvard University

Avi Robinson-Mosher- Scientific Programmer, DE Shaw Research

Devin Burrill- Scientist, Precision Biosciences Inc.

Matthew Robinson- Consulting

Matthew Niederhuber- Graduate Student, University of North Carolina

Cameron Myhrvold- Postdoctoral Fellow, Broad Institute of MIT/Harvard

Clovis Basier- Graduate Student, The Crick Institute

Kevin Hof- Graduate Student, École Polytechnique Fédérale de Lausanne

Michiel Karrenbelt- Institute of Systems Biology Zurich

David Lips- University of Amsterdam

Gladys Kibunyi- Charles River Lab

Johannes Bues- École Polytechnique Fédérale de Lausanne

Joost Verduijn- Ghent University

Drew MacKellar- University of Washington

Audam Chhun- PhD Candidate, University of Warwick

Thomas Perli- Delft University of Technology

Tyler J Ford- Scientist, Addgene Inc.

Lauren Kennedy-

Matthew Mattozzi- Senior Scientist, Conagen Inc.

Wade Hicks- Head of Operations and Lab Automation, KSQ Therapeutics Inc.  

Anna Chen- Life Scientist Specialist, L.E.K. Consulting

Buz Barstow- Assistant Professor of Biological Engineering, Cornell University

Wiggert Altenburg- Eindhoven University of Technology

Pia Mach- University of Tübingen

Takashi Imada- Professor, Kyoto University

Elena Schafer- Graduate student, University of Cambridge 

Max Van der Ploeg – Wageningen University and Research

Michael Tscherner- Fellow, University of Vienna

Nabeel Nissar

Sherry Gao- Postdoc, Harvard Medical University

Samuel O’Keefe

Nicholas Wong- Undergraduate, Harvard University

Aashna Shah- Undergraduate, Northeastern University

Ashton Omdahl- Graduate Student

Disha Trivedi- Undergraduate, Harvard University

Elizabeth Redfield- Discovery Immuno-oncology Intern