Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.
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Senior Staff Scientist
Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.
Roger Larken Chang
Associate Lab Director
Life Sciences Research Foundation Fellow 2014
Ph.D. Bioinformatics and Systems Biology, UC San Diego
B.A. Molecular and Cell Biology, UC Berkeley
Roger’s current research interests are in the study of proteome-wide oxidative stress resistance, as in the radioresistance of the polyextremophile Deinococcus radiodurans, and in engineering protein therapeutics to induce suspended animation in mammalian cells for preservation and to confer environmental stress resistance. Roger previously developed landmark models for structural systems biology of E. coli metabolism to identify growth-limiting enzymes for thermotolerance, antibiotic mechanisms, and human renal metabolism to characterize drug off-target effects in silico.
Departmental Fellow, Systems Biology
Ph.D. Physics, University of Pennsylvania
B.S. Physics, Stanford University
Elizabeth is interested in how bacterial populations regulate antibiotic tolerance and the appearance of rare cells with extreme phenotypes. She is currently designing new ways to measure bacterial signaling system activity.
2017 NIH F32 NRSA Postdoctoral Fellow
Ph.D. Pharmacology, University of Washington
Shannon is a a technical lead on a Wyss Institute Project focused on commercializing a CO2-based fermentation system for the production of tailored polymers. She is committed to developing synthetic biology and fermentation approaches to promote a more sustainable relationship with the planet.
Ph.D. Biological and Biomedical Science, Harvard University
Marika Ziesack is a Research Scientist working on the Wyss Institute Project “Circe” which aims to convert carbon dioxide waste streams into biodegradable polymers. Her research interests include metabolic engineering of non-standard bacteria, fermentation of sugar and gas feedstocks and bio-process design and analysis. She received her B.Sc. and M.Sc. from Heidelberg University and Ph.D. from Harvard University.
Ph.D. Biology, Heidelberg University
B.Sc. & M.Sc. Molecular Biotechnology
Dominik is a group leader for synthetic biology with focus on optogenetics and CRISPR-based tool development in the Health Data Science Unit at Heidelberg University Hospital and BioQuant, Germany. He is excited to visit the Silver lab to work on novel protein therapeutics for pancreatitis treatment.
2017 NIH F32 NRSA Postdoctoral Fellow
Ph.D. Chemical Engineering, Stanford
B.S. Chemical Engineering, University of Illinois at Urbana-Champaign
Amateur still trying to turn pro. Looking at controlling and recoding cells, after previously playing with natural product biosynthesis. Hoping to imagine again.
Ph.D. Chemical Biology, The Scripps Research Institute
A.B. Chemistry, Cornell University
Erika is a former peptide chemist interested in improving human-environmental relations. She is currently investigating how viruses play Jedi mind tricks on their host.
Ph.D. Bioengineering, Georgia Institute of Technology
S.B. Chemical Engineering, Massachusetts Institute of Technology
Tim is currently developing high throughput analyses of viral genes and their effects on intracellular signaling. In short, studying the viruses of today to better defend against the diseases of tomorrow.
Ph.D. Biophysics and Bioengineering, UC Santa Barbara
M.S. Nanoscience, Arizona State University
B.S. Biochemical Sciences, Harvard University
Dan has worked in a variety of scientific fields, including tumor angiogenesis, non-canonical amino acids, single-molecule force spectroscopy, self-assembled DNA nanostructures, and phase separation in biology. In the Silver lab, he is adding “little water bears” to this eclectic list.
Ph.D. Biochemistry, University of Wisconsin, Madison
B.S. Chemistry and Biochemistry, UMass Amherst
Mike wants to use biology to solve problems big and small. He is hoping his current project will allow him to travel across the galaxy in a biostatic sleep someday.
Ph.D., Harvard University
Suhyun is engineering gut bacteria to perform useful functions in humans. She enjoys dancing Rock’n’Roll and Zumba.
2019 Schmidt Science Fellow
Ph.D. Chemistry, University of British Columbia
Rebecca is a chemist trying her hand at some biology for her postdoc. She wants to use microbes to convert CO2 to chemicals and fuels.
Ph.D. Bioengineering, Georgia Institute of Technology
B.S. Chemical Engineering, University of Notre Dame
Monica is interested in using synthetic biology to design smarter diagnostics and therapeutics.
Ph.D. Chemistry, Harvard University
Tai is a postdoctoral fellow in Pam Silver’s lab who is interested in synthetic biology.
Nathan is investigating the molecular events that enable conditional behavior in biological systems. He is adding layers of requirement to proteins that function in these systems so they may only act when specific circumstances are met. Particularly, he is teaching cytokines when to pull the trigger on cell death.
B.S. Chemistry, Duke University
Jungmin is a graduate student in the Chemistry and Chemical Biology Program. She is interested in protein therapeutics and mammalian synthetic biology.
M.D. Candidate, Harvard Medical School
Harvard-MIT Health Sciences and Technology (HST)
BS Mathematics, MIT
Katie may be no Doogie Howser, but she’s still full of pep about her second career as a budding physician-scientist. She would love to talk your ear off about fusion proteins, dancing and the best coffee shops to camp out in. Her enthusiasm is fueled by a diet of red bull and leftover conference room pizza.
PhD Candidate in Chemistry and Chemical Biology
BS Chemistry, Yale University
Dan (not to be confused with Dan) is interested in renewable chemistry and is even more interested in getting microbes to do it for him. He also thinks self-replicating cyborg bacteria would be cool.
MSc Bioinformatics, Northeastern University (ongoing)
Julian is studying how animals can survive being dried, poisoned, frozen, or otherwise mistreated. He likes open-source science, unit tests, model organism genetics, history, and croquettes.
MSc candidate, Queen’s University (Canada)
Aaron is developing novel DNA damage biosensors to help human cells complain to him when they’re hurt. He likes the idea of sticking tardigrade proteins into these cells so they’ll just relax and be happy instead.
M.Sc. candidate Molecular Biotechnology, Heidelberg University (Germany)
B.Sc. Molecular Biotechnology, Heidelberg University (Germany)
Daniel is a visiting student interested in protein therapeutics and synthetic biology. He is working on novel fusion proteins for the treatment of pancreatitis.
Master’s student in Biochemistry, Eberhard Karls University Tübingen (ongoing)
B.Sc. Biochemistry, Eberhard Karls University Tübingen
Tobias is a visiting graduate student from Germany who investigates how viral genes impact intracellular signaling.
M.Sc. Molecular Biosciences – Systems Biology, Heidelberg University (ongoing)
B.Sc. Biochemistry, University of Tübingen
Fabian is a visiting graduate student working on the Biostasis project.
Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.
Christine recently graduated from Harvard with a degree in Chemistry, although she never was and never intends to be a “real chemist.” She likes to put DNA places it doesn’t normally go and seeing what happens. In her free time, she enjoys painting, reality TV, and explaining jokes to people.
Priya joined the lab in December 2018 and is studying disordered proteins to inform the design and delivery of novel therapeutics. Outside of lab, Priya enjoys gardening, Flamenco, and Billie Holiday.
Lauren is a research assistant in the Silver lab.
Hadley recently graduated from Harvard, where they studied bioengineering, although they are still a little unclear on what bioengineering actually means. Outside of lab, they can often be found whipping up much tastier experiments in the kitchen, laughing at jokes on the Internet, and occasionally reading an actual book.
Toluwalese Oladitan – undergrad, Harvard University
Nélida Leiva Eriksson – postdoc, Lund University, Sweden
Fernando Barbosa – Ph.D. candidate, University of Campinas, Brazil
Bryan Hsu – Assistant Professor, Dept of Biological Sciences, Virginia Tech
Finn Stirling – University of Cambridge
Sarabeth Buckley – University of Cambridge
Michael Melfi – VL50
Juline Savigny – masters student, Ecole Normale Superieure
Jonathan Naccache – masters student, Sup’Biotech Paris
Jérôme Zürcher – undergrad, ETH Zürich
Colin Molloy – undergrad
Maya Ordonez – undergrad, University of Chicago
Julia Rogers – undergrad, Emory University
Teagan Stedman – undergrad, Harvard University
David Riglar – Assistant Professor, Imperial College London
Sasha Naydich – Consultant
Emma Spady – Postdoc
Lorena Lyon – NOVA | PBS
Disha Trivedi – Harvard University
Jernej Turnšek – Research Fellow at J. Craig Venter Institute
Isaac Plant – Engineering and Product Development at Elm Innovations
Nathalie Gruber – Graduate student, University of Applied Life Sciences Vienna
Tobias Giessen – Assistant Professor, Dept of Bioengineering, University of Michigan
Jason Lee – Harvard University
Rachel Barocio – University of California Santa Cruz
Kassandra Boada – University of Massachusetts Amherst
Andrew Verdegaal- Graduate student, Yale University
Andy Shumaker- Indigo
Florian Bieberich- Graduate student, Ruprecht Karls University Heidelberg
Yu Heng Lau- Assistant Professor, University of Sydney
Kelsey Sakimoto- KulaBio
Kira Sarup-Lytzen- Graduate Student, Novo Nordisk Foundation Center for Biosustainability in Copenhagen
Jessica Polka- Director, ASAP Bio
Connor Horton- Undergraduate, Harvard University
John Oliver- ZBiotics
Alan Pacheco- Graduate Student, Boston University
Leon Liu- Senior Data Engineer, Athenahealth
Ryan Richardson- Postdoctoral Fellow, University of Maryland
Stephanie Hays- Postdoctoral Researcher, UC Berkeley
Brendan Colón-Data Scientist, Amazon
Kriti Lall- Investment Banking
Michael Baymv- Assistant Professor, Harvard Medical School
Marta Tomaselli- Graduate Student, University of Cambridge
Una Choi- Undergraduate, Harvard University
Avi Robinson-Mosher- Scientific Programmer, DE Shaw Research
Devin Burrill- Scientist, Precision Biosciences Inc.
Matthew Robinson- Consulting
Matthew Niederhuber- Graduate Student, University of North Carolina
Cameron Myhrvold- Postdoctoral Fellow, Broad Institute of MIT/Harvard
Clovis Basier- Graduate Student, The Crick Institute
Kevin Hof- Graduate Student, École Polytechnique Fédérale de Lausanne
Michiel Karrenbelt- Institute of Systems Biology Zurich
David Lips- University of Amsterdam
Gladys Kibunyi- Charles River Lab
Johannes Bues- École Polytechnique Fédérale de Lausanne
Joost Verduijn- Ghent University
Drew MacKellar- University of Washington
Audam Chhun- PhD Candidate, University of Warwick
Thomas Perli- Delft University of Technology
Tyler J Ford- Scientist, Addgene Inc.
Matthew Mattozzi- Senior Scientist, Conagen Inc.
Wade Hicks- Head of Operations and Lab Automation, KSQ Therapeutics Inc.
Anna Chen- Life Scientist Specialist, L.E.K. Consulting
Buz Barstow- Assistant Professor of Biological Engineering, Cornell University
Wiggert Altenburg- Eindhoven University of Technology
Pia Mach- University of Tübingen
Takashi Imada- Professor, Kyoto University
Elena Schafer- Graduate student, University of Cambridge
Max Van der Ploeg – Wageningen University and Research
Michael Tscherner- Fellow, University of Vienna
Sherry Gao- Postdoc, Harvard Medical University
Nicholas Wong- Undergraduate, Harvard University
Aashna Shah- Undergraduate, Northeastern University
Ashton Omdahl- Graduate Student
Disha Trivedi- Undergraduate, Harvard University
Elizabeth Redfield- Discovery Immuno-oncology Intern