Pamela Silver

Pamela Silver

Principal Investigator

Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.

Read more here.


Jeffrey Way

Jeffrey Way

Senior Staff Scientist

Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.


Roger Larken Chang

Roger Larken Chang

Associate Lab Director

Life Sciences Research Foundation Fellow 2014
Ph.D. Bioinformatics and Systems Biology, UC San Diego
B.A. Molecular and Cell Biology, UC Berkeley

Roger’s current research interests are in the study of proteome-wide oxidative stress resistance, as in the radioresistance of the polyextremophile Deinococcus radiodurans, and in engineering protein therapeutics to induce suspended animation in mammalian cells for preservation and to confer environmental stress resistance. Roger previously developed landmark models for structural systems biology of E. coli metabolism to identify growth-limiting enzymes for thermotolerance, antibiotic mechanisms, and human renal metabolism to characterize drug off-target effects in silico.

CV


Devin Burrill

Devin Burrill

Associate Lab Director

Post-doc, Protein Drug Development
PhD, Bioengineering & Biomedical Sciences
BS, Biochemistry & Chemistry

Devin is a research associate in the Silver lab.


Elizabeth Libby

Elizabeth Libby

Departmental Fellow, Systems Biology

Ph.D. Physics, University of Pennsylvania
B.S. Physics, Stanford University

Elizabeth is interested in how bacterial populations regulate antibiotic tolerance and the appearance of rare cells with extreme phenotypes. She is currently designing new ways to measure bacterial signaling system activity.


Research Scientists

Shannon Nangle

2017 NIH F32 NRSA Postdoctoral Fellow

Ph.D. Pharmacology, University of Washington

Shannon is a a technical lead on a Wyss Institute Project focused on commercializing a CO2-based fermentation system for the production of tailored polymers. She is committed to developing synthetic biology and fermentation approaches to promote a more sustainable relationship with the planet.

Marika Ziesack

Ph.D. Biological and Biomedical Science, Harvard University

Marika Ziesack is a Research Scientist working on the Wyss Institute Project “Circe” which aims to convert carbon dioxide waste streams into biodegradable polymers. Her research interests include metabolic engineering of non-standard bacteria, fermentation of sugar and gas feedstocks and bio-process design and analysis. She received her B.Sc. and M.Sc. from Heidelberg University and Ph.D. from Harvard University.


Postdoctoral Fellows

Erika Olson 

Ph.D. Chemical Biology, The Scripps Research Institute

A.B. Chemistry, Cornell University

Erika is a former peptide chemist interested in improving human-environmental relations. She is currently investigating how viruses play Jedi mind tricks on their host.

Timothy Chang

Ph.D. Bioengineering, Georgia Institute of Technology

S.B. Chemical Engineering, Massachusetts Institute of Technology

Tim is currently developing high throughput analyses of viral genes and their effects on intracellular signaling. In short, studying the viruses of today to better defend against the diseases of tomorrow.

Dan Nguyen

Ph.D. Biophysics and Bioengineering, UC Santa Barbara
M.S. Nanoscience, Arizona State University
B.S. Biochemical Sciences, Harvard University

Dan has worked in a variety of scientific fields, including tumor angiogenesis, non-canonical amino acids, single-molecule force spectroscopy, self-assembled DNA nanostructures, and phase separation in biology. In the Silver lab, he is adding “little water bears” to this eclectic list.

Michael Veling

Ph.D. Biochemistry, University of Wisconsin, Madison
B.S. Chemistry and Biochemistry, UMass Amherst

Mike wants to use biology to solve problems big and small. He is hoping his current project will allow him to travel across the galaxy in a biostatic sleep someday.

Rebecca Sherbo

2019 Schmidt Science Fellow

Ph.D. Chemistry, University of British Columbia

Rebecca is a chemist trying her hand at some biology for her postdoc. She wants to use microbes to convert CO2 to chemicals and fuels.

Monica McNerney

Ph.D. Bioengineering, Georgia Institute of Technology

B.S. Chemical Engineering, University of Notre Dame

Monica is interested in using synthetic biology to design smarter diagnostics and therapeutics.

Tai Ng

Ph.D. Chemistry, Harvard University

Tai is a postdoctoral fellow in Pam Silver’s lab who is interested in synthetic biology.

Jungmin Lee

Ph.D. Chemistry and Chemical Biology, Harvard University

B.S. Chemistry, Duke University

Jungmin is a postdoc in the Silver lab. She is interested in protein therapeutics and mammalian synthetic biology.

Samuel Lim

Ph.D. Chemical Engineering, UC Berkeley
B.S. Chemical-Biological Engineering, Massachusetts Institute of Technology

Sam has spent years at Berkeley playing with protein nanofibers from extremophiles, teaching them to assemble in interesting ways like Lego blocks. In the Silver Lab, he is trying to engineer a unique set of proteins that can freeze cells and protect them from injury.


Graduate Students

Nathan Rollins

Nathan is investigating the molecular events that enable conditional behavior in biological systems. He is adding layers of requirement to proteins that function in these systems so they may only act when specific circumstances are met. Particularly, he is teaching cytokines when to pull the trigger on cell death.


Kasia Kready

B.Sc. Biomedical/Medical Engineering, Dartmouth College

Kasia is a grad student in the Silver lab.


Kailyn Doiron

Ph.D. student in Systems, Synthetic, and Quantitative Biology
M.A. Biotechnology, Boston University
B.A. Biochemistry and Molecular Biology, Boston University

Kailyn is a graduate student in SSQBio and is a molecular and cell biologist at heart. She is very interested in making your cells do things they don’t normally do in order to create novel therapeutics. She was a competitive dancer in a past life and can be seen busting a move in studios or her kitchen in her free time. She loves binge-watching TV and tending to or talking about her five cats and seven orchids.


Rui Tong Quek

Ph.D. student

Rui is a PhD student in the Silver lab.


 

Research Staff

Kathleen Buhl

Lab Manager

Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.

Priya Jani

Priya joined the lab in December 2018 and is studying disordered proteins to inform the design and delivery of novel therapeutics. Outside of lab, Priya enjoys gardening, Flamenco, and Billie Holiday.


Sloane Weiss

Sloane recently graduated from Harvard, where they studied bioengineering, although they are still a little unclear on what bioengineering actually means. Outside of lab, they can often be found whipping up much tastier experiments in the kitchen, laughing at jokes on the Internet, and occasionally reading an actual book.


Michela Oster

Michela recently graduated with a degree in Biochemistry and one in English. She enjoys studying biomedical applications of intrinsically disordered proteins, protein folding mechanisms, and pretty much anything biochemistry related. When she’s not in lab she’s usually reading or eating food.


Colin Malloy

Colin recently graduated with degrees in Biology and Spanish from Hobart and William Smith College.


Rotation Students


Undergrads


Recent Alumni

For information on recent Silver Lab alums please contact meghan_vanorden@hms.harvard.edu.