Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.
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Senior Staff Scientist
Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.
Roger Larken Chang
Associate Lab DirectorLife Sciences Research Foundation Fellow 2014
Ph.D. Bioinformatics and Systems Biology, UC San Diego
B.A. Molecular and Cell Biology, UC Berkeley
Roger’s current research interests are in the study of proteome-wide oxidative stress resistance, as in the radioresistance of the polyextremophile Deinococcus radiodurans, and in engineering protein therapeutics to induce suspended animation in mammalian cells for preservation and to confer environmental stress resistance. Roger previously developed landmark models for structural systems biology of E. coli metabolism to identify growth-limiting enzymes for thermotolerance, antibiotic mechanisms, and human renal metabolism to characterize drug off-target effects in silico.
Associate Lab DirectorPost-doc, Protein Drug Development
PhD, Bioengineering & Biomedical Sciences
BS, Biochemistry & Chemistry
Devin is a research associate in the Silver lab.
Departmental Fellow, Systems Biology
Ph.D. Physics, University of Pennsylvania
B.S. Physics, Stanford University
Elizabeth is interested in how bacterial populations regulate antibiotic tolerance and the appearance of rare cells with extreme phenotypes. She is currently designing new ways to measure bacterial signaling system activity.
2017 NIH F32 NRSA Postdoctoral Fellow
Ph.D. Pharmacology, University of Washington
Shannon is a a technical lead on a Wyss Institute Project focused on commercializing a CO2-based fermentation system for the production of tailored polymers. She is committed to developing synthetic biology and fermentation approaches to promote a more sustainable relationship with the planet.
Ph.D. Biological and Biomedical Science, Harvard University
Marika Ziesack is a Research Scientist working on the Wyss Institute Project “Circe” which aims to convert carbon dioxide waste streams into biodegradable polymers. Her research interests include metabolic engineering of non-standard bacteria, fermentation of sugar and gas feedstocks and bio-process design and analysis. She received her B.Sc. and M.Sc. from Heidelberg University and Ph.D. from Harvard University.
Ph.D. Chemical Biology, The Scripps Research Institute
A.B. Chemistry, Cornell University
Erika is a former peptide chemist interested in improving human-environmental relations. She is currently investigating how viruses play Jedi mind tricks on their host.
Ph.D. Bioengineering, Georgia Institute of Technology
S.B. Chemical Engineering, Massachusetts Institute of Technology
Tim is currently developing high throughput analyses of viral genes and their effects on intracellular signaling. In short, studying the viruses of today to better defend against the diseases of tomorrow.
Ph.D. Biophysics and Bioengineering, UC Santa Barbara
M.S. Nanoscience, Arizona State University
B.S. Biochemical Sciences, Harvard University
Dan has worked in a variety of scientific fields, including tumor angiogenesis, non-canonical amino acids, single-molecule force spectroscopy, self-assembled DNA nanostructures, and phase separation in biology. In the Silver lab, he is adding “little water bears” to this eclectic list.
Ph.D. Biochemistry, University of Wisconsin, Madison
B.S. Chemistry and Biochemistry, UMass Amherst
Mike wants to use biology to solve problems big and small. He is hoping his current project will allow him to travel across the galaxy in a biostatic sleep someday.
2019 Schmidt Science Fellow
Ph.D. Chemistry, University of British Columbia
Rebecca is a chemist trying her hand at some biology for her postdoc. She wants to use microbes to convert CO2 to chemicals and fuels.
Ph.D. Bioengineering, Georgia Institute of Technology
B.S. Chemical Engineering, University of Notre Dame
Monica is interested in using synthetic biology to design smarter diagnostics and therapeutics.
Ph.D. Chemistry, Harvard University
Tai is a postdoctoral fellow in Pam Silver’s lab who is interested in synthetic biology.
Ph.D. Chemistry and Chemical Biology, Harvard University
B.S. Chemistry, Duke University
Jungmin is a postdoc in the Silver lab. She is interested in protein therapeutics and mammalian synthetic biology.
Ph.D. Chemical Engineering, UC Berkeley
B.S. Chemical-Biological Engineering, Massachusetts Institute of Technology
Sam has spent years at Berkeley playing with protein nanofibers from extremophiles, teaching them to assemble in interesting ways like Lego blocks. In the Silver Lab, he is trying to engineer a unique set of proteins that can freeze cells and protect them from injury.
Nathan is investigating the molecular events that enable conditional behavior in biological systems. He is adding layers of requirement to proteins that function in these systems so they may only act when specific circumstances are met. Particularly, he is teaching cytokines when to pull the trigger on cell death.
B.Sc. Biomedical/Medical Engineering, Dartmouth College
Kasia is a grad student in the Silver lab.
Ph.D. student in Systems, Synthetic, and Quantitative Biology
M.A. Biotechnology, Boston University
B.A. Biochemistry and Molecular Biology, Boston University
Kailyn is a graduate student in SSQBio and is a molecular and cell biologist at heart. She is very interested in making your cells do things they don’t normally do in order to create novel therapeutics. She was a competitive dancer in a past life and can be seen busting a move in studios or her kitchen in her free time. She loves binge-watching TV and tending to or talking about her five cats and seven orchids.
Rui Tong Quek
Rui is a PhD student in the Silver lab.
Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.
Priya joined the lab in December 2018 and is studying disordered proteins to inform the design and delivery of novel therapeutics. Outside of lab, Priya enjoys gardening, Flamenco, and Billie Holiday.
Sloane recently graduated from Harvard, where they studied bioengineering, although they are still a little unclear on what bioengineering actually means. Outside of lab, they can often be found whipping up much tastier experiments in the kitchen, laughing at jokes on the Internet, and occasionally reading an actual book.
Michela recently graduated with a degree in Biochemistry and one in English. She enjoys studying biomedical applications of intrinsically disordered proteins, protein folding mechanisms, and pretty much anything biochemistry related. When she’s not in lab she’s usually reading or eating food.
Colin recently graduated with degrees in Biology and Spanish from Hobart and William Smith College.