Pamela Silver is the Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology at Harvard Medical School. She is also a full member of the Wyss Institute of Biologically Inspired Engineering. She was one of the first members of the Department of Systems Biology and the first Director of the Harvard University Graduate Program in Systems Biology.
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Senior Staff Scientist
Jeff’s current research interests are in therapeutic protein development and bioenergy. As a senior staff scientist at the Wyss, he is also supporting faculty-driven efforts in DNA synthesis and DNA assembly. Before coming to the Wyss, he was Director of Structural Biology and Director of Intellectual Property at EMD Serono, a major protein-focused pharmaceutical company, where he designed protein drugs. Previously, he was a Director of Intellectual Property and Director of Communications there. He has published numerous articles on drug development, synthetic biology, nervous system development, and bacterial genetics, and holds several patent applications and issued patents. He received his Ph.D. and B.A from Harvard University.
Roger Larken Chang
Associate Lab DirectorLife Sciences Research Foundation Fellow 2014 Ph.D. Bioinformatics and Systems Biology, UC San Diego B.A. Molecular and Cell Biology, UC Berkeley Roger’s current research interests are in the study of proteome-wide oxidative stress resistance, as in the radioresistance of the polyextremophile Deinococcus radiodurans, and in engineering protein therapeutics to induce suspended animation in mammalian cells for preservation and to confer environmental stress resistance. Roger previously developed landmark models for structural systems biology of E. coli metabolism to identify growth-limiting enzymes for thermotolerance, antibiotic mechanisms, and human renal metabolism to characterize drug off-target effects in silico.
Associate Lab Director
Senior Scientist, Obsidian Therapeutics & Precision Biosciences
Boston Biomedical Innovation Center Fellow, Protein Drug Development, MIT & Wyss Institute at HMS
NIH NRSA Postdoctoral Fellow, Protein Drug Development, MIT & Wyss Institute at Harvard Medical School
Ph.D., Bioengineering, Biological, & Biomedical Sciences, Harvard Medical School
B.S., Biochemistry with Honors, University of Chicago
B.S., Chemistry with Honors, University of Chicago
Devin is an associate lab director of the Silver Lab. She is originally from Chicago but has lived in Boston for many years. She has a background in bioengineering, cancer biology, biochemistry, and drug development. Her current research interests include DNA/protein engineering, protein therapeutics, genetic circuit design, CAR-T design, synthetic biology in general, and business development. She is a pioneer in building complex genetic circuits in stable yeast and mammalian cell lines for studying long-term responses to DNA damage. Her post-doctoral work on engineering versions of erythropoietin and anti-Ebola antibodies has contributed significantly to Harvard’s initiative to promote protein drug engineering and to moving products out of the lab and into the world. Before returning to Boston, she worked at two CAR-T start-ups, where she assisted with construct design and cell line engineering. She then went on to do independent scientific consulting. Devin recently came back to Harvard to work as an associate lab director of the Silver Lab, and she is so happy to be back in the Systems Biology Department!
2017 NIH F32 NRSA Postdoctoral Fellow
Ph.D. Pharmacology, University of Washington
Shannon is a a technical lead on a Wyss Institute Project focused on commercializing a CO2-based fermentation system for the production of tailored polymers. She is committed to developing synthetic biology and fermentation approaches to promote a more sustainable relationship with the planet.
Ph.D. Biological and Biomedical Science, Harvard University
Marika Ziesack is a Research Scientist working on the Wyss Institute Project “Circe” which aims to convert carbon dioxide waste streams into biodegradable polymers. Her research interests include metabolic engineering of non-standard bacteria, fermentation of sugar and gas feedstocks and bio-process design and analysis. She received her B.Sc. and M.Sc. from Heidelberg University and Ph.D. from Harvard University.
Ph.D. Bioengineering, Georgia Institute of Technology
S.B. Chemical Engineering, Massachusetts Institute of Technology
Tim is currently developing high throughput analyses of viral genes and their effects on intracellular signaling. In short, studying the viruses of today to better defend against the diseases of tomorrow.
Ph.D. Biophysics and Bioengineering, UC Santa Barbara M.S. Nanoscience, Arizona State University B.S. Biochemical Sciences, Harvard University
Dan has worked in a variety of scientific fields, including tumor angiogenesis, non-canonical amino acids, single-molecule force spectroscopy, self-assembled DNA nanostructures, and phase separation in biology. In the Silver lab, he is adding “little water bears” to this eclectic list.
Ph.D. Biochemistry, University of Wisconsin, Madison
B.S. Chemistry and Biochemistry, UMass Amherst
Mike wants to use biology to solve problems big and small. He is hoping his current project will allow him to travel across the galaxy in a biostatic sleep someday.
Ph.D. Chemistry, Harvard University
Tai is a postdoctoral fellow in Pam Silver’s lab who is interested in synthetic biology.
Ph.D. Chemical Engineering, UC Berkeley
B.S. Chemical-Biological Engineering, Massachusetts Institute of Technology
Sam has spent years at Berkeley playing with protein nanofibers from extremophiles, teaching them to assemble in interesting ways like Lego blocks. In the Silver Lab, he is trying to engineer a unique set of proteins that can freeze cells and protect them from injury.
Takeda Science Foundation Fellow 2020
Ph.D. Medical Science, Kyushu University, Japan
M.D. Tohoku University, Japan
Hide has a wide array of expertise, including internal medicine, cancer-related experiments, and artificial intelligence. In the Silver lab, he is integrating both biological and computational approaches for next-generation medicine.
B.Sc. Biomedical/Medical Engineering, Dartmouth College
Kasia is a grad student in the Silver lab.
Ph.D. student in Systems, Synthetic, and Quantitative Biology
M.A. Biotechnology, Boston University
B.A. Biochemistry and Molecular Biology, Boston University
Kailyn is a graduate student in SSQBio and is a molecular and cell biologist at heart. She is very interested in making your cells do things they don’t normally do in order to create novel therapeutics. She was a competitive dancer in a past life and can be seen busting a move in studios or her kitchen in her free time. She loves binge-watching TV and tending to or talking about her five cats and seven orchids.
Rui Tong Quek
Rui is a PhD student in the Chemical Biology program and is broadly interested in synthetic biology and cell line engineering. She is currently working on characterizing host-virus interactions developing platforms for antiviral drug discovery. Outside of science, she enjoys playing the ukulele and watching horror films.
Ethan Jones is a PhD student in the SSQB program interested in creating synthetic biology platforms that will allow the field to solve more complex problems. Outside of lab he builds computers and attempts to breed tropical fish.
M.S. candidate Biomedical Engineering / Molecular Bioengineering, ETH Zurich
B.S. Mathematics, ETH Zurich
Raffael is a Masters student and student intern in the Silver Lab working on high throughput analyses of viral genes and their effects on intracellular signaling. Raffael is excited about Synthetic Biology and engineering novel functions and circuits on a cellular and genetic level. As a Swiss, he lives on regular chocolate supplies from home and is willing to share some of it from time to time.
B.Sc. Molecular Biotechnology, Heidelberg University
Thorge is a visiting graduate student from Germany working on the pancreatitis project. He is testing and designing protein drugs and is interested in methods improving drug targeting.
M.Sc. candidate Biotechnology, ETH Zurich, Switzerland
B.Sc. Biology, ETH Zurich, Switzerland
Benjamin is a visiting graduate student in the Silver lab working on SARS-CoV-2 research. He is excited about the combination of computational and wet-lab approaches to Synthetic Biology. Outside of the laboratory, he enjoys climbing and skiing.
Kathy has been managing the Silver lab since 2006. When she’s not whipping the Silverinos into shape, she plays hockey and enjoys hiking. She’s recently discovered her spirit animal is the squirrel.
Priya joined the lab in December 2018 and is studying disordered proteins to inform the design and delivery of novel therapeutics. Outside of lab, Priya enjoys gardening, Flamenco, and Billie Holiday.
Sloane recently graduated from Harvard, where they studied bioengineering, although they are still a little unclear on what bioengineering actually means. Outside of lab, they can often be found whipping up much tastier experiments in the kitchen, laughing at jokes on the Internet, and occasionally reading an actual book.
Colin recently graduated with degrees in Biology and Spanish from Hobart and William Smith College.
Vivek is working on the Circe project, and is really interested in biotechnology climate change mitigation and in situ resource utilization for Mars habitation and deep space exploration. He studied biochemistry at University of Massachusetts Amherst. When not in the lab he loves hiking and comedy.
Merle is a first year in the Biological and Biomedical Sciences Ph.D. program at Harvard Medical School and is a rotation student in the Silver Lab.